Ischemic stroke following a wasp sting – a rare complication: a case report
- 87 Downloads
Wasp stings are commonly encountered worldwide and result in a variety of clinical manifestations including local and systemic reactions. Neurological and vascular complications are rarely reported following a wasp sting.
A 69-year-old Sri Lankan Tamil man presented to our hospital with focal neurological deficit following multiple wasp stings; the deficit was confirmed to be an acute infarction on magnetic resonance imaging scan. He was screened for metabolic risk factors which were negative and he had a normal two-dimensional echocardiogram and normal carotid arteries in carotid duplex which excluded potential sources of thromboembolism.
Treating physicians should be aware of the rare but possible complication of ischemic stroke following a case of wasp sting.
KeywordsWasp sting Ischemic stroke Vascular
Magnetic resonance imaging
Wasp stings are commonly encountered worldwide. They can result in a variety of clinical manifestations of which local reactions are the commonest . Neurological and vascular manifestations, including ischemic strokes [2, 3, 4], are very rarely reported following wasp sting. The pathophysiology of ischemic stroke following wasp sting is probably due to vasoactive, inflammatory and thrombogenic properties of wasp venom [5, 6, 7]. An alternative mechanism may be vascular spasms caused by venom [8, 9, 10]. We report a previously healthy Sri Lankan man presenting with an ischemic stroke following a wasp sting.
We report the case of a 69-year-old Sri Lankan Tamil man from Kandy who presented to the toxicology unit following a wasp sting. He was stung by three wasps in the evening and was brought to the toxicology unit of Teaching Hospital, Peradeniya with acute onset slurring of speech, deviation of mouth to the left side, with right-side weakness of his body. He had mild local reaction at the sites of wasp sting, but no anaphylaxis. He was apparently well before this event without any chronic medical illnesses.
On admission to the toxicology unit he was conscious and rational. He was neither pale nor plethoric. He had a regular pulse of 80 beats per minute and blood pressure of 140/90 mmHg. On clinical examination he had no cardiac murmurs or carotid bruits. He had expressive aphasia, right-side upper motor neuron-type facial nerve palsy, with grade four weakness of the right side of his body.
Wasps are members of the order Hymenoptera, suborder Apocrita . Wasp sting events have occurred worldwide, especially in developing countries with swarm attack. Despite the common occurrence of insect stings and local and systemic allergic reactions , there are few reports of vascular complications such as myocardial infarction or stroke following wasp stings.
Our case reports a previously healthy man developing an acute stroke following a wasp sting. This case report clearly shows that as few as three wasp stings can give rise to ischemic cerebral infarctions. It is unlikely that the cause of ischemic stroke is due to anaphylaxis-induced hypotension as suggested by the territory. As our patient had no known predisposing causes of strokes, it is extremely likely that the wasp sting caused the event in a previously healthy vascular anatomy.
Few cases of cerebral infarction following wasp sting have been reported in the literature. However, the species has not been positively identified in any of the cases. In the case reported by Crawley et al. , the victim had been hypotensive for a period of time and had a prolonged stay in an intensive care unit. The cause of the occipital lobe infarction may have been due to many other known risk factors. In another case report, three wasp stings were followed by collapse and tonic-clonic seizure . There was no recoded hypotension. The patient was treated with adrenaline, steroids, and phenobarbitone and later found to have hemiparesis and computed tomography (CT) confirmed cerebral infarction. In another two case reports the patients died after wasp sting and at postmortem cerebral infarctions were found . In the latter two cases there was no positive identification of the species and there was no mention of other known risk factors for ischemic strokes. We have excluded common risk factors of ischemic strokes and it is likely that the toxins present in the venom are the most likely cause of ischemic stroke.
Wasp venom contains a wide array of amines, peptides, and enzymes that are responsible for local and systemic reactions. The first set of information on wasp venom at a molecular level was given in the study by Sookrung et al. , which studied the venom of Vespa affinis and classified the venom into typical venom components, and structural and housekeeping proteins. The venom of Vespa affinis and Vespa tropica appear to be similar. The pathophysiology of ischemic infarctions following wasp sting is yet to be described. Wasp venom contains vasoactive, inflammatory, and thrombogenic peptides and amines including histamines, leukotrienes, and thromboxane. Leukotrienes and thromboxane cause platelet aggregation and vasoconstriction . Direct toxic effects are mediated by mixtures of low molecular weight compounds such as serotonin, histamine, acetylcholine, and several kinins . Phospholipases in wasp venom can elicit an immunoglobulin E response resulting in mast cell activation which will in turn release histamine and lead to the release of a cascade of de novo synthesized chemical mediators .
An alternative mechanism may be vasospasm. In the literature there are few cases of myocardial infarction occurring after bee sting has been reported. Massing et al.  reported a case of inferior myocardial infarction in a young man following bee sting. He was followed up with a coronary angiogram after the acute phase and his coronary arteries were angiographically healthy. Valla et al.  also reported myocardial infarction in a 45-year-old man following an anaphylactic reaction to a wasp sting. Ceyhan et al.  reported a non-ST elevation acute myocardial infarction in a patient envenomed by a bee sting. However, in these instances a coronary angiogram revealed healthy non-occluded coronary arteries and probably the initial myocardial injury was caused by vasospasm. Similar phenomena can operate in the cerebral circulation and can cause acute focal neurological deficits. However, irreversible neurological deficit makes it unlikely in our case.
The ischemic stroke in our patient could be attributed to wasp venom which is vasoactive, inflammatory, and thrombogenic.
Physicians encounter large numbers of hymenopteran sting cases each year. These patients typically present with local reactions. Systemic manifestations, such as anaphylaxis, are less common. Neurological manifestations are extremely rare. Treating physicians should be aware of the rare but possible complication of ischemic stroke in a case of wasp sting.
Availability of data and materials
Data sharing not applicable to this article as no datasets were generated or analyzed during the current study.
CD and IBG examined, assessed, and were involved in the management of the patient. Both authors collected data and analyzed. Both authors read and approved the final manuscript.
Ethics approval and consent to participate
Ethical approval was not obtained for the publication of this case report as this does not involve sharing of the personal details of the patient.
Consent for publication
Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
The authors declare that they have no competing interests.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
- 6.Wilson JD, Braunwald E, Isselbacher KJ, Wallace JF. Disorders caused by venoms, bites and stings. In: Wilson JD, Braunwald E, Isselbacher KJ, editors. Harrison’s principles of internal medicine. New York: Mc Graw Hill; 1992. p. 2187–94.Google Scholar
- 7.Braunwald E, Handin RI, Loscalzo J. Hemostasis, thrombosis, fibrinolysis, and cardiovascular disease. In: Braunwald E, editor. Heart disease. Philadelphia: WB Saunders; 1998. p. 1767–88.Google Scholar
- 8.Massing JL, Bentz MH, Schlesser P, Dumitru C, Louis JP. Myocardial infarction following a bee sting. Apropos of a case and review of the literature. Ann Cardiol Angeiol (Paris). 1997;46:311–5.Google Scholar
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.